DYSPORT® 500U Botulinum Toxin Type A – Purified Neurotoxin Complex Product Overview Dysport® is a highly purified form of Botulinum Toxin Type A, derived from Clostridium botulinum. Each vial contains 500 units (U) of the active neurotoxin. It is approved for both aesthetic and therapeutic indications. Aesthetic Indication: Moderate to Severe Glabellar Lines Dysport® is used to temporarily reduce the appearance of frown lines between the eyebrows by targeting the corrugator and procerus muscles. By limiting muscle activity in this area, it helps smooth existing lines and prevent the formation of new ones, restoring a more relaxed and youthful look. Mechanism of Action When injected intramuscularly, Dysport® inhibits the release of acetylcholine at the neuromuscular junction. This results in localized, reversible muscle relaxation, with the effect confined to the targeted muscles, leaving surrounding areas unaffected. Clinical Characteristics Onset of Action: 2–5 days post-injection Peak Effect: Around 14 days Duration of Effect: Approximately 3–4 months, varying by treatment area and individual response Reconstitution & Dosage Reconstitute with preservative-free 0.9% sodium chloride as follows: 1 mL saline → 50 U per 0.1 mL 2.5 mL saline → 20 U per 0.1 mL 5 mL saline → 10 U per 0.1 mL Use reconstituted solution within 24 hours. Follow approved dosing guidelines specific to each indication. Approved Uses Aesthetic Applications Glabellar lines Forehead lines Crow’s feet (lateral canthal lines) Therapeutic Applications Cervical dystonia Upper and lower limb spasticity Chronic migraine prevention Axillary hyperhidrosis Blepharospasm Chemical & Physical Properties Molecular Formula: C₆₇₆₀H₁₀₄₄₇N₁₇₄₃O₂₀₁₀S₃₂ Molar Mass: ~149,320 g/mol Log P: –0.368 (indicating low lipid solubility) Stability: Stable at 14.86 °C / 0.1011 MPa Storage Instructions Before Reconstitution: Store lyophilized vials at 2–8 °C. Do not freeze. After Reconstitution: Store at 2–8 °C and use within 24 hours. Safety & Precautions Common side effects include pain, swelling, bruising at the injection site, headache, flu-like symptoms, and transient eyelid or brow ptosis. Rare but serious adverse events may involve difficulty swallowing, breathing, or speaking, particularly at higher doses. Administration should always be carried out by a qualified healthcare professional.
